What Are the Best Choline Supplements for Cognitive Function?

Knowledgeable users of nootropics know that it’s not a matter of if they should use choline, but rather which choline source they should use. The quality and strength of the most popular choline supplements vary dramatically—not all are created equal. Because of this, it’s important to educate yourself on the differences and the benefits of each choline source.

If you’ve spent any time researching nootropics, you’ve most likely heard the term “cholinergic” tossed around. Cholinergic compounds are substrates for acetylcholine, which is the brain’s most prominent memory and learning neurotransmitter. Simply put, most choline sources (cholinergic substances) will positively influence acetylcholine levels in the brain once ingested. The increase in acetylcholine can offset potential headaches received from using racetams such as Piracetam or Aniracetam. Racetams and other nootropics for creativity, memory, and focus go hand in hand with high-quality sources of choline. You rarely see one taken without the other.

Choline is frequently associated with the B vitamin complex and is a crucial nutrient for the body and brain at every age. Supplements for acetylcholine are considered safe, highly beneficial, and have little to no adverse side effects. Neurotransmitter acetylcholine is the mediator for learning and muscle contraction. It is found all throughout the body and serves two primary functions:

Neuromuscular Junction

For neuromuscular junction, motor neurons release acetylcholine for more efficient muscle activation. Choline supplementation is popular among body builders and athletes for this reason. Improvements in muscle-activating functionality translate to better lifts at the gym and stronger performances on the field. Increased acetylcholine production means enhancements in both physical and mental endurance, as well as increased power output.


As a neuromodulator inside the brain, acetylcholine alters the processing of information, rather than point to point data transmission. Choline is known as the best nootropic for memory and learning, and for a good reason. Improved processing of external stimuli leads to better memory formation and recall, as well as cleaner focus and concentration. Neuroprotection and prevention of cognitive decline are also noted benefits with the regular use of choline supplements.

Benefits of Choline Supplementation

Choline supplementation is vital if you want your nootropic stack to be useful, or to amplify its current effects. There are plenty of food sources available that can boost acetylcholine production. However, for noticeable improvements in cognitive function or physical endurance, you’ll need an additional choline source. Particularly, one that can easily cross the blood-brain barrier to interact with neurochemicals in a beneficial manner.

The benefits of a reliable choline source are numerous. Whether you’re an athlete, a student, or an entrepreneur, the potential gains of supplementing choline include:

Overall improvements in cognitive function and mental clarity

Enhancements in memory, mental energy, focus, and concentration

Significantly improves mood without interfering with sleep or generating restlessness

Increased physical power output

Fatigue reduction with improved mental and physical endurance

Increased growth hormone production and fat oxidation in healthy young adults

Neuroprotection and prevention of cognitive decline

Significant cognition improvements in those who have Alzheimer’s, dementia or other neurodegenerative diseases

Types of Acetylcholine Supplements

As you can see, the benefits of choline are numerous. Today’s article explores the most popular choline sources used to improve cognitive function and physical performance. We will cover the following acetylcholine supplements in detail: Choline Bitartrate / Lecithin, CDP-Choline (Citicoline), Alpha GPC (Alpha-Glycerophosphocholine / Choline Alfoscerate), and a lesser-known super-concentrated choline source, Sharp GPC™ Active.

Choline Bitartrate / Lecithin

Choline bitartrate supplements are the most readily available choline sources on the market. You’ll find them in drug stores, supermarkets, retailers, and any store that stocks general health products. Unfortunately, choline bitartrate is also the cheapest, simplest, and least effective form of choline with extremely limited nootropic benefit. Choline bitartrate, lecithin, and water soluble choline chloride all struggle to cross the blood-brain barrier effectively. The inability to efficiently cross the blood-brain barrier means they have very low bioavailability. Low bioavailability means these choline sources are unable to communicate with neurochemicals in the brain impactfully.

Although choline bitartrate is 41% choline by weight (1,000mg dose confers 410mg of choline), the choline delivered is not sufficient for cognitive enhancement. If you’re looking for nootropics for focus and concentration, this is one choline supplement to skip. Other choline sources such as Alpha GPC, or Sharp GPC™ Active have been shown to provide greater neural choline concentrations.

CDP-Choline (Citicoline)

CDP-choline supplements are much more common in the nootropic community. CDP-choline (also known as cytidine diphosphate choline or citicoline) is both a uridine and choline prodrug. The cytidine portion being the precursor to uridine, and the choline portion being the precursor to acetylcholine. Uridine plays a vital role in neural membrane synthesis and improving memory and cognition. Citicoline is 18.5% choline by weight (1,000mg dose confers 185mg of choline), which is lower than choline bitartrate. However, the choline delivered is more useful for cognitive enhancement. CDP-choline metabolizes quickly and reliably. The higher bioavailability allows your brain to increase production of neurotransmitter acetylcholine within an hour of ingestion.

Alpha GPC (Alpha-Glycerophosphocholine / Choline Alfoscerate)

Until recently, Alpha GPC has been sitting on top of the throne as the best choline supplement available. We discuss this cognitive booster thoroughly in our Alpha GPC review. Structurally, it is composed of phosphate, glycerol, and choline. Once ingested, it quickly metabolizes into glycerophosphate and choline upon absorption. The Alpha GPC supplement is 40% choline by weight (1,000mg dose confers 400mg of choline). Like CDP-choline, Alpha GPC delivers a more useful form of choline to the brain that is more bioavailable. The high bioavailability allows for a quick and positive impact on acetylcholine production. Due to its higher concentration of choline, Alpha GPC has historically been the favorite choline source among nootropic users.

Sharp GPC™ Active

Sharp GPC™ Active is a revolutionary leap forward in the industry of brain health. It is an extremely concentrated liquid matrix of Alpha GPC at its highest purity. Sharp GPC™ is approximately 85% choline by weight (1,000mg dose confers 850mg of choline), making it 112% more concentrated than Alpha GPC. Not only is Sharp GPC™ Active the most bioavailable source of choline on the market, but it provides the greatest benefit requiring the lowest dose. Dramatic improvements in memory, mood, focus, energy levels and physical performance occur through regular Sharp GPC™ consumption.

What Is the Best Choline Source?

Choline supplements are a fundamental component of every nootropic stack. The best choline source currently available is Sharp GPC™ Active, the flagship ingredient featured in our free-to-try nootropic formula, CogniTune™.

Choline by Weight Summary

Sharp GPC™ Active 85%
Alpha GPC 40%
CDP-Choline (Citicoline) 18.5%
*Choline Bitartrate / Lecithin 41%

*Choline Bitartrate / Lecithin is known to have poor bioavailability

What is your favorite acetylcholine supplement? Let us know about your experience with choline supplementation in the comments below!

The mind is not a vessel to be filled but a fire to be kindled.

~ Plutarch

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