Trans-Resveratrol Vs Resveratrol - What Are The Differences?

Trans-Resveratrol Vs Resveratrol - What Are The Differences?

Hey there, health enthusiasts! You may have heard the buzz about resveratrol, a powerful compound found in grapes, red wine, and other plants, that has been making waves in the world of health and wellness. This fascinating compound has been linked to a whole host of benefits, from supporting heart health to promoting healthy aging, and it has caught the attention of researchers, doctors, and people looking to improve their overall well-being.

In today’s post, we’re going to dive deep into the world of resveratrol, specifically comparing trans-resveratrol and cis-resveratrol. There are some key differences between these two forms of resveratrol, and understanding them can help you make the best choices for your health.

Defining Trans-Resveratrol and Resveratrol

Before we dive into the differences, let’s take a moment to define trans-resveratrol and resveratrol. Resveratrol is a type of polyphenolic compound called a stilbene, which is found in plants such as grapes, berries, and peanuts. This compound exists in two isomeric forms: cis-resveratrol and trans-resveratrol.

Trans-resveratrol is the more biologically active and stable form of resveratrol. It’s the one that has been extensively studied for its potential health benefits. In fact, when people talk about the benefits of resveratrol, they’re usually referring to trans-resveratrol.

Cis-resveratrol, on the other hand, is the less stable and less biologically active form of resveratrol. It’s not as well-studied as its trans counterpart, and it’s generally considered to be less significant in terms of its potential health benefits.

resveratrol from grapes

Sources of Trans-Resveratrol and Resveratrol

Now that we’ve defined the two stars of the show, let’s talk about where you can find them. Both trans-resveratrol and cis-resveratrol can be found in various plant sources. Some common sources include:

Grapes: Resveratrol is found in the skin of grapes, with red grapes containing higher concentrations than white grapes.

Wine: Red wine is a popular source of resveratrol, thanks to the fermentation process and the use of grape skins.

Berries: Blueberries, cranberries, and mulberries contain significant amounts of resveratrol, with the highest concentrations typically found in the skin.

Peanuts: Both raw and roasted peanuts contain resveratrol, with higher concentrations found in the peanut skin.

It’s important to note that while these sources contain both cis- and trans-resveratrol, the trans isomer is more readily absorbed and utilized by the body, making it the more desirable form for health purposes.

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The Benefits of Trans-Resveratrol and Resveratrol

Now that we’ve covered the basics, let’s dive into the exciting world of potential health benefits! Both trans-resveratrol and resveratrol have been linked to a variety of positive effects on the body, but it’s important to remember that trans-resveratrol is considered the more biologically active form. Here, we’ll discuss some of the most promising benefits associated with these compounds, and we’ll provide scientific sources to back up these claims:

Heart Health: One of the most well-known benefits of resveratrol is its potential to support heart health. Studies have shown that trans-resveratrol may help to improve blood flow, reduce inflammation, and prevent the oxidation of LDL (“bad”) cholesterol, which can contribute to a reduced risk of heart disease. Additionally, trans-resveratrol has been found to promote the production of nitric oxide, which helps to relax blood vessels and lower blood pressure.

Anti-Aging and Longevity: Resveratrol has gained significant attention for its potential anti-aging effects. Research suggests that trans-resveratrol may activate a family of proteins called sirtuins, which are involved in regulating cellular health and lifespan. By activating sirtuins, trans-resveratrol may help to protect cells from damage, reduce inflammation, and promote healthy aging.

Antioxidant and Anti-Inflammatory Properties: Both trans-resveratrol and cis-resveratrol exhibit antioxidant and anti-inflammatory properties. However, due to the higher bioavailability and stability of trans-resveratrol, it is considered to be more effective in combating oxidative stress and inflammation. These properties may contribute to the prevention of chronic diseases, such as heart disease, cancer, and neurodegenerative disorders.

Brain Health: Trans-resveratrol has been shown to have potential neuroprotective effects, which may help to preserve cognitive function and prevent the onset of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. These effects may be due to its antioxidant and anti-inflammatory properties, as well as its ability to promote blood flow to the brain.


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Trans-Resveratrol Vs Cis-Resveratrol: The Showdown

Now that we’ve explored the benefits of both trans-resveratrol and cis-resveratrol, it’s time for the ultimate showdown! Let’s compare these two forms of resveratrol and see which one comes out on top:

Bioavailability and Stability: Trans-resveratrol is more stable and bioavailable than cis-resveratrol, making it more readily absorbed and utilized by the body. This is a significant factor when considering the potential health benefits of resveratrol, as a higher bioavailability means more of the compound is able to reach its target cells and exert its positive effects.

Biological Activity: As we’ve discussed throughout this post, trans-resveratrol is the more biologically active form of resveratrol. This means that it is more likely to have a greater impact on various health outcomes, such as heart health, anti-aging, and brain health, compared to cis-resveratrol.

Research and Evidence: The vast majority of research on resveratrol has focused on trans-resveratrol, as it is considered to be the more relevant form in terms of potential health benefits. This means that there is a more substantial body of evidence supporting the use of trans-resveratrol for various health outcomes compared to cis-resveratrol.


In conclusion, while both trans-resveratrol and cis-resveratrol are forms of the powerful compound resveratrol, it’s clear that trans-resveratrol is the more biologically active, stable, and well-studied form. This is the form that is responsible for most of the health benefits attributed to resveratrol, making it the preferred choice for those looking to improve their overall well-being.

So, the next time you reach for a glass of red wine or a handful of blueberries, you can feel good knowing that you’re not only enjoying a delicious treat but also potentially reaping the health benefits of trans-resveratrol. And if you’re considering adding a resveratrol supplement to your routine, make sure to look for one that contains a high potency resveratrol extract, as these are most likely to have isolated and concentrated trans-resveratrol in a form with the most potential to support your health goals.

Remember, as with any supplement or dietary change, it’s important to consult with a healthcare professional before making any major adjustments. They can help you determine the best course of action for your individual needs and ensure that you’re making the most informed decisions for your well-being.

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