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Alpha GPC Review: Benefits, Side Effects, and Dosage Guide

There’s a good chance that if you’re reading this Alpha GPC review, you already have some basic knowledge on choline. Cholinergic compounds are some of the most discussed nootropics on the market. All the best nootropic stacks contain a reliable choline source to aid in your brain’s production of acetylcholine. Acetylcholine is dubbed the “learning neurotransmitter” and is responsible for just that—memory and learning. A steel trap memory would be the envy of students, entrepreneurs, and executives around the world. Thus, one of the most common goals of choline supplementation is to improve your ability to retain information.

Choline is considered a dietary supplement in the United States, with a composition similar to that of the B vitamin complex. In Europe, choline is regulated and sold under the brand names Delecit and Gliatilin with prescriptions. There are plenty of dietary sources of choline available. However, choline concentrations high enough for nootropic benefit require supplementation. Choline, while naturally present in the body, is a water-soluble compound extracted from purified soy lecithin for commercial resale. Once a supplement like Alpha GPC is absorbed, it is metabolized into both glycerophosphate and choline (the precursor to acetylcholine).

There are several different types of choline circulating the nootropic community. Two common types are CDP-Choline (Citicoline) and Choline Bitartrate / Lecithin. The subject of today’s review is Alpha GPC, also known as Choline Alfoscerate or Alpha-Glycerophosphocholine. We won’t dive into detail on the other two choline sources. Our previous article on the types of choline supplements makes the comparison in detail. Our focus for this review will be on the benefits of Alpha GPC and correct dosing information. We will also cover potential side effects, the supplement’s half-life, and Alpha GPC liquid.

Alpha GPC Benefits


Alpha GPC benefits the brain in many ways. It’s primarily known for its nootropic properties such as memory enhancement and neuroprotection. Numerous clinical studies back Alpha GPC for demonstrating the following health benefits:

Improved focus, concentration, memory, and cognitive function

Increased mental clarity and brain fog reduction through acetylcholine synthesis

Enhanced mental and physical endurance and lessening of fatigue

Improvements in physical power output and recovery after overexertion

Enhanced fat oxidation and production of human growth hormone in young adults

Overall mood enhancement without sleep interference or restlessness

Neuroprotective properties to shield and preserve an aging brain

Substantial cognitive improvements in Alzheimer’s patients, or those suffering from other neurodegenerative diseases

All the listed Alpha GPC benefits are significant. But, the real strength comes from its potentiating properties when stacked with other nootropics. Additional choline works to amplify the cognitive enhancement effects of nootropics such as Huperzine A, Phosphatidylserine, and Caffeine. The increased production of acetylcholine can also prevent headaches when using racetams, ampakines, or other synthetic nootropic supplements.

Given these long-term health benefits and cognitive boosting abilities, Alpha GPC becomes vital for building a sharper mind. Its high bioavailability allows it to penetrate the blood-brain barrier quickly and efficiently. The choline goes to work rapidly, reducing brain fog and enhancing long-term memory with regular use. We will discuss potential side effects later in our Alpha GPC review.

Alpha GPC Dosage


What is the correct Alpha GPC dosage? How much Alpha GPC should you take? These questions have answers that vary depending on your goals. Your age and personal health also play a role. With that said, there are some dosing ranges you’ll want to stay within for optimal benefit. An important fact to remember is that Alpha GPC is 40% choline by weight. This ratio means that a 1,000mg dose of Alpha GPC confers to approximately 400mg dietary choline. The dosing recommendations below refer to the total amount of Alpha GPC ingested—not the 40% choline output.

For Cognitive Enhancement & Neuroprotection

For nootropic users seeking cognitive enhancement and neuroprotection, keep your dose in the 300-600mg range. In general, this Alpha GPC dose is both recommended and well-tolerated. Daily dosing of 300-1200mg cumulatively has been documented as safe and effective for most users. You can take this amount all at once or split your servings throughout the day or as needed. You’ll want to begin consumption at the lower end of this spectrum. Once you’ve assessed tolerance and effect, you may increase your dose in a stepwise fashion.

For Physical Performance & Growth Hormone Boost

Alpha GPC stacks very well with the top nootropics for energy. For increasing power output and physical performance, consume 600-1000mg of Alpha GPC 30-45 minutes before exercise. Whether it’s a gym session or athletic performance, this dose has been proven beneficial. Increasing your Alpha GPC dosage beyond this point does not necessarily translate to better performance or increased HGH production. Feel free to experiment with this by slowly increasing your dose to assess tolerance and benefit.

Alpha GPC Side Effects


The Alpha GPC side effects are few and far between. It is a well-tolerated cholinergic supplement when used within the recommended dosing range. The side effects of Alpha GPC listed below are rare. They typically only surface when going far beyond the recommended dose.

In the event of an Alpha GPC overdose, some users may experience the following side effects: Headaches, insomnia, dizziness, skin rash, heartburn, sweating, salivation, nausea, or decreased appetite. Again, these are very rare. In cases of insomnia, a GABA supplement may be beneficial. If you happen to experience any of these side effects, you’ve gone too far in your dose. Simply reduce Alpha GPC intake back to an acceptable amount for your body.

Alpha GPC Half-Life


In our review of Alpha GPC, we’ve covered many of its cognitive enhancement and health benefits. But how long do they last, and how long does it take for this choline supplement to work?

The Alpha GPC half-life is around 4-6 hours but is said to peak within 1-2 hours of ingestion. For those who supplement multiple times per day, it is recommended to keep the doses 4-6 hours apart from each other.

Liquid Alpha GPC


Liquid Alpha GPC is available in the form of Sharp GPC™ Active, a revolutionary step forward in choline supplementation. Sharp GPC™ Active is 85% choline by weight, making it 112% more concentrated than Alpha GPC. CogniTune™, our brand-new nootropic formula, features Sharp GPC™ Active as its flagship ingredient. It is the purest and best Alpha GPC supplement available on the market.

Our liquid gel capsule boasts HydraTech Precision Dosing™ Technology. This scientific breakthrough uses microencapsulated ingredients allowing for up to a 98% absorption rate. Solid and powder nootropics usually have active ingredient absorption rates of less than 20%. If you’re looking for super-concentrated liquid Alpha GPC that is highly bioavailable, Sharp GPC™ Active is the best option.

We hope you found our Alpha GPC review helpful. Let us know about your experience with Alpha GPC in the comments below!

The difference between a successful person and others is not a lack of strength, not a lack of knowledge, but rather a lack of will.

~ Vince Lombardi

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November 11th, 2016|
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Hi, this may be interesting you: Alpha GPC Review: Benefits, Side Effects, and Dosage Guide! Here's the link: https://www.cognitune.com/alpha-gpc-review/