What is Modiodal? Review of Uses, Side Effects & Proper Dosage

Home/What is Modiodal? Review of Uses, Side Effects & Proper Dosage


Modiodal is an international prescription formulation of the wakefulness-promoting drug Modafinil. Belonging to a class of substances known as eugeroics, Modafinil provides the user with enhanced mental alertness and wakefulness. As a prescription brain pill, Modafinil is particularly useful in the treatment of sleep disorders such as narcolepsy. Physicians often prescribe it for such purposes. More recently, Modafinil has become known for its ability to increase mental performance in healthy individuals during high stress, high reward situations.

Modafinil has received significant attention from the media as a sort of wonder pill more than any other nootropic agent. There are also several articles reporting on the use of Modafinil by Wall Street executives. With comparisons abound to the fictional limitless pill NZT-48 from the Hollywood blockbuster Limitless, the drug has a relatively widespread reputation for improving aspects of memory and mental performance. This cognitive boost is particularly relevant when either sleep may be elusive or high mental concentration is required.

These qualities suggest that Modafinil may also be a safer alternative to current treatment options for disorders such as ADHD (Attention-Deficit/Hyperactivity Disorder) and other focus related deficits. Users of Modafinil commonly report on the drug’s relative subtlety and smoothness when compared to the widely prescribed dopaminergic stimulants such as Adderall or Ritalin. We cover this topic extensively in our write-up Modafinil vs. Adderall. The Modafinil experience is void of the “come down” effect and jitteriness associated with traditional ADHD medication.

The precise mechanism of action behind Modafinil’s effect on wakefulness and mental performance isn’t entirely known. Histamine release may play a role in the drug’s ability to enhance alertness, but more studies need to be done to confirm this. Moreover, despite not directly releasing dopamine, extrasynaptic dopamine levels have been observed to be slightly elevated in the brains of those who have consumed Modafinil. Considered to be safe and well tolerated, the user must be aware of certain issues regarding dosage and side effects. These precautions ensure they will safely benefit from Modafinil’s effect on mental performance, treating brain fog, and alleviation of ADHD symptoms.

Modiodal Dosage

It is important to note that Modafinil’s biological half-life is relatively long with an average of 15 hours. Because of this, a small Modiodal dosage is recommended to start. For example, 50mg of an administered dose of Modiodal 100mg will remain in the body after more than half a day. This feature of the substance has the potential to disturb the user’s sleep cycle. A significant amount of the Modafinil dose will remain in the user’s system even with morning administration. New users who are taking a higher Modiodal dosage may have difficulty sleeping. Although, the issue resolves itself as individuals become more tolerant to the drug’s effect.

Modiodal 200mg or 100mg?

During the first week, the suggested daily dose is half of a 100mg tablet or a quarter of a 200mg tablet, first thing in the morning. This dosage allows the user to become familiar with the drug’s effects in a controlled manner. Ultimately, the user may titrate all the way up to a 400mg Modiodal dosage daily, although this may be considered a high dose. Users are frequently able to consume 200mg of Modiodal, which is usually sufficient for enhancing motivation and energy for an entire day. To find the optimum dose, the user should increase consumption in a stepwise fashion and observe any differences in effect. The user should ingest the smallest dosage possible that remains effective for improving mental performance.

Modiodal Side Effects

Modafinil is considered to be milder than other stimulant or wakefulness-promoting medications. As a result, Modafinil possesses a relatively low addiction liability when compared to the likes of Adderall. Moderately common adverse Modiodal side effects include reports of headaches, nausea, dizziness, anxiety, insomnia, nervousness, irritability, and gastrointestinal problems. It is recommended to discontinue the use of Modiodal if the negative side effects increase in severity after several days.

Often, issues such as headaches and insomnia diminish in intensity with increased tolerance to the medication. Additionally, you may find that a top choline supplement such as Alpha GPC or Huperzine A can work to reduce the frequency and intensity of headaches. Very rare adverse reactions requiring medical attention include skin rashes as a result of Stevens-Johnson syndrome. For the vast majority of users, negative Modiodal side effects are rare. It’s considered safe, with several years of research suggesting efficacy with minimal adverse reactions.

Modiodal for ADHD

There is some promise that Modafinil (in the form of Modiodal internationally or Provigil in the United States) may represent a well-needed and safer alternative to traditional ADHD medication. An even safer natural substitute for Adderall for long-term use is the nootropic Phosphatidylserine (PS). PS is well-known for reducing ADHD related symptoms with little to no side effects.

Prescription ADHD drugs including amphetamines and methylphenidates carry a negative reputation which frequently deters potential new users. A study of over 900 children and adolescents concluded that Modafinil produced a reduction in symptoms related to ADHD as well as problem social behaviors.

The United States does not recognize Modafinil as a treatment for ADHD. In spite of this fact, many physicians are starting to write off-label prescriptions for this purpose. Modiodal may be taken to improve the user’s ability to focus on and complete tasks without interruption. Numerous anecdotal reports suggest that Modafinil produces a motivational state that allows the mind to focus and concentrate.

Final Thoughts on Modiodal

Overall, Modiodal is a potent psychostimulant for nootropic users interested in maintaining a high level of mental performance. Whether the user is interested in the maintenance of optimal brain performance during stressful times or alleviating symptoms of ADHD, Modiodal is a smart drug worth considering. Please always consult a doctor or physician before using prescription medications as “smart drugs” for off-label use.

There are no great limits to growth because there are no limits of human intelligence, imagination, and wonder.

~ Ronald Reagan

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June 3rd, 2016|
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